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[DOWNLOAD] "Reaction of Thiocarboxanilide Derivatives of 2-Phenylimino-3-Phenyl-4-Thiazolidinone and 1,3-Diphenyl-2-Thioxo-4-Imidazolone with Hydrazonoyl Halides and Active Chloromethylene Compounds (Report)" by Natural Science " Book PDF Kindle ePub Free

Reaction of Thiocarboxanilide Derivatives of 2-Phenylimino-3-Phenyl-4-Thiazolidinone and 1,3-Diphenyl-2-Thioxo-4-Imidazolone with Hydrazonoyl Halides and Active Chloromethylene Compounds (Report)

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eBook details

  • Title: Reaction of Thiocarboxanilide Derivatives of 2-Phenylimino-3-Phenyl-4-Thiazolidinone and 1,3-Diphenyl-2-Thioxo-4-Imidazolone with Hydrazonoyl Halides and Active Chloromethylene Compounds (Report)
  • Author : Natural Science
  • Release Date : January 01, 2011
  • Genre: Engineering,Books,Professional & Technical,
  • Pages : * pages
  • Size : 236 KB

Description

1. INTRODUCTION 1,3,4-Thiadiazole and its derivatives possess an interesting biological activity probably conferred to them by the strong aromaticity of this ring system [1]. It is known that many of its derivatives have antibacterial [2], antimicrobial [3], antimycobacterial [4,5], antifungal [6,7], antidepressant [8], anti-inflammatory [9], analgesic [10] activities and cardiotonic [11] action being notable. Besides, the thiazoline ring is associated with a variety of pharmacological actions, including antimicrobial [12], anti-inflammatory [13], anti-tumor [14], and antioxidant [15] actions. Moreover, imidazolinone derivatives constitute an important class of therapeutic activities such as anticonvulsant [16], potent central nervous system (CNS) depressant [17], and acting on [alpha]-adrenergic and/or imidazoline receptors [18]. Recently, some new imidazolinone derivatives have been reported as antimicrobial [19,20], histamine [H.sub.3]-receptor antagonist [21] and L-DOPA prodrugs in the treatment of Parkinson's disease [22]. Some workers have recognized 5-imidazolone as having anticancer activity [20]. Prompted by these findings and due to our interest in the synthesis of new heterocyclic compounds with potential biological activities [23-26] and in continuation of our work on the synthesis of hetaryl-ylidene derivatives [27-29], we report herein the synthesis of some new 1,3,4-thiadiazoline-(thiazoline)-2-hetarylylidene derivatives that might be of pharmacological importance.


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